J. Veerman, J. Klein, R. M. Aben
Sep 1, 2002
Citations
0
Influential Citations
10
Citations
Journal
European Journal of Organic Chemistry
Abstract
Functionalised piperidines are frequently encountered structural motifs in bioactive compounds and in natural products.[1] The piperidine ring is often present as a substructure in drug-like molecules.[2] A well-known example is Ritalin (1, methyl α-phenyl-2-piperidinylacetate), used for the treatment of attention deficiency/hyperactivity disorder (ADHD) in children (Scheme 1).[3] Some other piperidinecontaining natural products that show interesting biological activity are febrifugine (2)[4] and ( )-lobeline (3).[5] Consequently, a plethora of synthetic routes affording functionalised piperidines has been developed.[6] In many groups, including ours, N-acyliminium ion pathways towards these scaffolds have been developed over the years.[7] In conjunction with this work, a solid-phase approach that