Guo Li
2009
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Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesis Asp6 by solid-phase method.METHODS Fmoc-Asp(OBzl)-OH was applied as the raw material,and o-Benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate as the coupling reagent.The protected Asp6 was synthesized on resin gradually by microwave irradiation,clearaged by trifluoroacetic acid,and purified.RESULTS Chemical structure of product was confirmed by 1HNMR and MS.CONCLUSION Microwave method can significantly shorten the time of solid-phase reaction and increase the yield.