Jinfang Zhang, Wesley P. Goodloe, B. Lou
2004
Citations
0
Influential Citations
6
Citations
Journal
Molecular Diversity
Abstract
An efficient method for solid-phase constructionof tetrahydro-1,4-benzodiazepin-2-one scaffold is described.Polymer-bound 4-(bromomethyl)-3-nitrobenzoic acid was reactedwith α-amino acid methyl esters, followed by nitro groupreduction and hydrolysis. Subsequent intramolecular cyclizationand alkylation at N(4) afforded the structurally diverse productsin high yields and excellent purities.