A. Galanis, F. Albericio, M. Grøtli
Sep 16, 2009
Citations
0
Influential Citations
60
Citations
Journal
Organic letters
Abstract
An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amino acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave irradiation as an energy source.