M. Chaudhuri, V. Najjar
May 1, 1979
Citations
0
Influential Citations
20
Citations
Journal
Analytical biochemistry
Abstract
Abstract A method is described for the synthesis of the naturally occurring tetrapeptide tuftsin (Thr-Lys-Pro-Arg). This stimulates phagocytosis of granulocytes and macrophages. Trifluoromethanesulfonic acid is used to cleave the tetrapeptide from its supporting resin in solid-phase synthesis. This reagent also causes deprotection of several protecting groups in bifunctional residues. The most significant is the complete removal of the tosyl group from NG-tosyl-arginine-resin ester.