Y. Bakhbakhi, P. Charpentier, S. Rohani
Sep 3, 2009
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Journal
Organic Process Research & Development
Abstract
In this study the solubility of beclomethasone-17,21-dipropionate in acetone, methanol, and ethanol as model systems to investigate the supercritical gas antisolvent micronization process was performed over a wide range of temperatures. Beclomethasone-17,21-dipropionate is an inhaled steroid used for the treatment of asthma. Experimental determination of the solubility of beclomethasone-17,21-dipropionate in the three solvents was achieved by employing a gravimetric technique over the temperatures range 24.5−62.5 °C. The solubility data were modeled using the group contribution parameters and UNIversal QUAsi-Chemical (UNIQUAC) theory. The binary parameters of the UNIQUAC model were calculated by employing the experimental solubility data. Good predictions of the solubility measurements were achieved using the UNIQUAC model.