Xinbao Li, Mingju Wang, Yang Cong
Mar 1, 2017
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0
Influential Citations
7
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Journal
The Journal of Chemical Thermodynamics
Abstract
Abstract The solubility of 2-amino-4-chlorobenzoic acid in eleven organic solvents including N -methyl-2-pyrrolidone, ethanol, n -propanol, isopropanol, ethyl benzene, toluene, n -butanol, acetonitrile, ethyl acetate, 1,4-dioxane and acetone were determined experimentally using the isothermal saturation method over a temperature range from (278.15 to 313.15) K under 101.2 kPa. Within the temperature range studied, the mole fraction solubility of 2-amino-4-chlorobenzoic acid in the solvents increased with a rise of temperature. On the whole, they obeyed the following order from high to low in the selected solvents: N- methyl-2-pyrrolidone > acetone > 1, 4-dioxane > ethyl acetate > ethanol > isopropanol > n -propanol > n -butanol > acetonitrile > toluene > ethyl benzene. The solubility values obtained for 2-amino-4-chlorobenzoic acid were correlated with the modified Apelblat equation, λh equation, Wilson model and NRTL model. The largest values of root-mean-square deviation ( RMSD ) and relative average deviation ( RAD ) were 8.25 × 10 −4 and 3.35%, respectively. The modified Apelblat equation correlated the experimental solubility best on the basis of the result of AIC analysis. Furthermore, the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient ( γ 1 ∞ ) and reduced excess enthalpy ( H 1 E, ∞ ) at infinitesimal concentration were determined. Solubility and thermodynamic studies are very important for optimizing the purification process of 2-amino-4-chlorobenzoic acid.