H. Uchida, Izumi Usui, and Asami Fuchita
Sep 10, 2004
Citations
1
Influential Citations
10
Citations
Journal
Journal of Chemical & Engineering Data
Abstract
The solubility of (S)-Boc-piperazine ((S)-3-[[(1,1-dimethylethyl)amino] carbonyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester) and the racemic compound of (S)- and (R)-Boc-piperazines in supercritical carbon dioxide was measured in the pressure range from (9 to 20) MPa and at temperatures (308.2, 318.2, and 328.2) K using a flow-type apparatus. The experimental solubilities of (S)-Boc-piperazine and the racemic compound at the present conditions were in the range of (2 × 10-4 to 7 × 10-3 and 4 × 10-5 to 6 × 10-4) in mole fraction, respectively. The solubilities were correlated by the Soave−Redlich−Kwong (SRK) equation of state with two binary interaction parameters. The present model gave a good correlation of all the experimental solubility data. The two binary interaction parameters were correlated by linear functions of temperature.