F. Shakeel, M. A. Bhat, N. Haq
Aug 5, 2014
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Journal
Journal of Chemical & Engineering Data
Abstract
The aim of the present investigation was to measure and correlate the solubility of N-(4-chlorophenyl)-2-(pyridin-4-ylcarbonyl)hydrazinecarbothioamide [isoniazid (INH) analogue] in five different pure solvents, namely, ethanol, ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), and isopropyl alcohol (IPA) at (298.15 to 338.15) K using the shake flask method. The experimental solubilities of INH analogue were regressed with Apelblat equation with root-mean-square deviations in the range of (0.22 to 4.42) %. The correlation coefficients were observed in the range of 0.996 to 0.999, indicating good fitting of experimental data. The solubility of INH analogue was found to increase with an increase in temperature in each solvent investigated. The mole fraction solubility of INH analogue was found to be highest in PEG-400 (1.08 × 10–1 at 298.15 K) followed by EG (7.70 × 10–3 at 298.15 K), PG (7.38 × 10–3 at 298.15 K), IPA (1.13 × 10–3 at 298.15 K), and ethanol (6.47 × 10–4 at 298.15...