P. Simamora, J. M. Álvarez, S. Yalkowsky
Feb 1, 2001
Citations
7
Influential Citations
190
Citations
Quality indicators
Journal
International journal of pharmaceutics
Abstract
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (>1000-fold) increase in the aqueous solubility of rapamycin.