M. Z. Siddiqui, A. Sharma, S. Kumar
Aug 1, 1996
Citations
0
Influential Citations
4
Citations
Journal
International journal of biological macromolecules
Abstract
Conformation of chemically synthesized tetrapeptide tuftsin, an important immunomodulator, with the sequence Thr-Lys-Pro-Arg-OH has been studied in aqueous solution as well as in a number of organic solvents viz. trifluoroethanol (TFE), methanol and dioxane by circular dichroism (CD) spectroscopy which reveals preferential occurrence of mixture of random coil and beta-turns, that has already been predicted as bioactive conformation of this peptide.