P. Kuehl, M. Carducci, P. Myrdal
Dec 1, 2003
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Influential Citations
6
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Journal
Acta Crystallographica Section E-structure Reports Online
Abstract
Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine–chlorine interactions.