Z. Hong, Z. Hong, Jianjun Li
Feb 1, 2016
Citations
1
Influential Citations
3
Citations
Journal
RSC Advances
Abstract
Solvent-free condensation of phenylacetonitriles with 4-unsubstituted nitroaromatic compounds to produce a series of arylcyanomethylenequinone oximes was described in the presence of KF/nano-γ-Al2O3 under high-speed vibration milling conditions, and the products were obtained in moderate to excellent yields at short reaction times. Moreover, the product α-(3-methyl-4-(hydroxyimino)-2,5-cyclohexadien-1-ylidene) benzeneacetonitrile 3b has been confirmed by X-ray diffraction analysis. The formation of nitroso isomer from oxime was measured by 1H NMR in acetone-d6 under different temperatures. In vitro antitumor studies showed that several arylcyanomethylenequinone oximes displayed strong antitumor activity against Caki-1 and 769-P.