W. Ross
Apr 1, 1967
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The preparation of 6-methoxy-, - n -amylamino, -anilino-, -benzylamino-, phenylhydrazino-, -phenylazo, -(2-hydroxyethylthio)-, and -benzylthio-nicotinarmide is described. The results of a preliminary screening of these new compounds and some related 6-substituted nicotinic acids and nicotinamides against the transplanted Walker rat carcinoma and the mouse lymphoid leukaemia, L 1210, are reported. Moderate activity against the leukaemia is shown by 6-chloro-, -methoxy-, -anilino- and phenylazo-nicotinamide.