C. L. Rose, P. N. Harris, K. K. Chen
Jun 1, 1959
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Journal
The Journal of pharmacology and experimental therapeutics
Abstract
Two pyrrolizidine alkaloids, supinine and lasiocarpine, have been investigated pharmacologically. In confirmation of our previous results in mice and rats, a single intravenous injection of lasiocarpine was followed by acute necrosis of the liver of golden hamsters and a rhesus monkey. Hypoprothrombinemia occurred in rats injected with lasiocarpine. Single intravenous injections of supinine, on the other hand, had no hepatotoxic action in mice and rats. This alkaloid appeared to have a very weak atropine-bike action.