S. James, D. Jeffery, R. Waring
Mar 1, 1970
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Rabbits have been dosed with bromocyclopentane, bromocyclohexane and bromocycloheptane and the excretion of bromine (estimated as bromide), glucosiduronic acid and ethereal sulphate measured. With all three compounds there is a relatively rapid excretion of bromide accounted for by the formation of a bromine-containing glucosiduronic acid. The glucosiduronic acids isolated as their tri-acetyl methyl esters are conjugates of bromocycloalkanols. Evidence is presented that hydroxylation of the bromocycloalkane occurs at position 2. The extent of hydroxylation increases with increasing ring size.