F. Dallacker, G. Reichrath, G. Schnackers
1980
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Journal
Zeitschrift fur Naturforschung. Section C, Biosciences
Abstract
We describe the preparation of 4,7-dimethyl-benzo[1,3]dioxole-5-carboxylic acid (7 d), 5,6-dimethyl-benzo [1,3]dioxole-4-carboxylic acid (14), 6,7-dimethoxy-benzo [1,4]dioxane-5-carboxylic acid (16), 7,8-dimethyl-3,4-dihydro-2 H-benzo [1,5]dioxepin-6-carboxylic acid (17), and of 8,9-dimethyl-2,3,4,5-tetrahydro-benzo [1,6]dioxocin-carboxylic acid (18) by reaction of the lithiumcompounds with carbondioxide. For testing the spasm-activity of benzo [1,3]dioxole-5-carboxylic acids (Table I), benzo [1,3]dioxole-4-carboxylic acids (Table II), and naphtho [1,3]dioxole-carboxylic acids (Table III) these componds were orally given to mice.