F. Marcucci, A. Guaitani, J. Kvetina
Nov 1, 1968
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Influential Citations
77
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Journal
European journal of pharmacology
Abstract
Abstract Diazepam showed an antimetrazol activity which was longer-lasting in mice than in rats. The levels of diazepam in blood and brain were similar in both species but N-desmethyl metabolites ofdiazepam accumulated in mouse brain while they were practically undetectable in rat brain. The three main metabolites of diazepam, namely N-methyloxazepam, N-desmethyldiazepam and oxazepam showed strong anticonvulsant activity in mice.