P. Jenner, J. Gorrod, A. Beckett
Sep 1, 1973
Citations
0
Influential Citations
39
Citations
Journal
Xenobiotica
Abstract
Abstract1. Marked species, but not sex differences, were observed in the metabolism of R-(+)- and S-(-)-nicotine to cotinine and the diastereoisomeric nicotine-1′-N-oxides by liver 10 000 × g supernatant preparations from rats, rabbits, mice, guinea-pigs and hamsters.2. S-(-)-nicotine formed predominantly R,S-cis-nicotine-1′-N-oxide, whereas R-(+)-nicotine gave predominantly S,R-trans-nicotine-1′-N-oxide; stereoselective metabolism to cotinine also occurred. A stereo-selective site for the N-oxidation of nicotine is proposed to explain these results.