N. Chang, T. Muramatsu, H. Schmid
Jun 21, 1973
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0
Influential Citations
11
Citations
Quality indicators
Journal
Biochimica et biophysica acta
Abstract
Abstract 2-Methyl[I-14C]hexadecanol and [2-14C]heptadecan-2-ol were administered intracerebrally to 18-day-old rats and incorporation of radioactivity into the brain lipids was determined after 6 and 24 h. The 2-methyl branched primary alcohol was found to be incorporated into the ethanolamine phosphatides as 1-O-2'-methylhexadecyl glycerol. The rate of formation of the 2'-methyl branched glycerophosphatides was considerably slower than that observed for the formation of the natural straightchain derivatives. 2'-Methyl branched alk-1-enyl glycerophosphatides could not be detected. The long-chain secondary alcohol was not incorporated as such into the glycerophosphatides. Metabolic degradation of either precursor was extensive; radioactivity derived from the secondary alcohol was found mainly in the corresponding methyl ketone after 6 h, and mainly in 16:0, 18:0 and 18:1 acyl moieties after 24 h.