Ola M. Abdallah
Jun 29, 2010
Citations
0
Influential Citations
10
Citations
Journal
International Journal of Analytical Chemistry
Abstract
Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5–45 μg mL−1 for guaifenesin and 10–80 μg mL−1 for dropropizine. Both drugs were also successfully determined in their dosage forms.