C. Rambabu
May 10, 2017
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Abstract
Dothiepin also known as dosulopin, is a thio analogue of amitriptyline which has been used extensively. It is a safe and effective agent for the treatment of major depressive disorders [1]. Although the onset of action is comparable to that of other tricyclic antidepressants, dothiepin may cause fewer intolerable side effects and have less cardiotoxicity than the other compounds. In addition, dothiepin reduces the anxiety associated with some major depressive episodes. These features suggest that dothiepin may be particularly helpful for treating anxious depressed patients and patients who have underlying cardiac disease or who are elderly [2] (Figure 1).