S. Xin
2013
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0
Influential Citations
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Journal
Chinese Journal of Magnetic Resonance
Abstract
Eight 2-aryloxymethyl-1H-benzimidazole acetic acid hydrazides(4) have been synthesized by hydrazinolysis of the corresponding esters 3.Among them,the compounds 4c,4d,4f and 4g are new.The structures of the target compounds 4 were characterized by elemental analysis,IR and 1H NMR.1H and 13C NMR signals assignments and spatial structure of representative compound 4e are confirmed by its two-dimensional(1H-1H COSY,HSQC,HMBC and NOESY) NMR spectra.The tautomerism of compound 4e were studied by the variable-temperature experiment and solvent experiment(DMSO-d6 and CDCl3).The experimental results indicate that the target compounds 4 in DMSO at room temperature exist in the tautomeric keto and imine enol forms,and the dominant keto form isomer consists 88.2%~92.6%,while the imine enol form is the only structure in CDCl3 at room temperature.