Ross A. Johnson, K. P. Moder, T. Ward
May 1, 1992
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0
Influential Citations
2
Citations
Journal
Journal of Organic Chemistry
Abstract
The synthesis of 4-(hydrorymethyl)thiazole derivatives from the corresponding 4-(chloromethyl)-4-hydroxythiazole derivatives have been speculated to proceed through spirooxirane intermediates. NMR spectroscopy was used to provide evidence for the existence of such an intermediate in the synthesis of 4-(hydrorymethyl)-2-[(dimethylamino)methyl]thiazole. Erperimental conditions for the optimumformation and stabllization of a suspect intermediate were determined and spectral data obtained to support the speculated structure