Jun Li, J. Uzawa, Y. Doi
Aug 15, 1998
Citations
0
Influential Citations
6
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Dimeric (R)-3-hydroxybutanoic acid (3HB) was found to form an inclusion complex selectively with β-cyclodextrin (β-CD) in aqueous solution. The complex formation was confirmed by the changes of 1H and 13C NMR spectra of both dimeric 3HB and β-CD in D2O solution. The continuous variation experiments showed the formation of a 1 : 1 inclusion complex. The dissociation constants at various temperatures between 15 and 47 °C were determined and the thermodynamic analysis of the complex formation was performed. The results indicated that the complex formation is enthalpically favorable but entropically unfavorable. We propose that the 3HB unit with carboxy end-group is located in the narrow side of the β-CD cavity.