S. M. Ali, S. Upadhyay, A. Maheshwari
Jul 24, 2007
Citations
0
Influential Citations
17
Citations
Journal
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Abstract
Desloratadine (DES) is an antihistamine used in the treatment of allergies and chronic urticaria. 1H NMR spectroscopic study of varying ratios of DES and β-Cyclodextrin (β-CD) in D2O suggests the formation of a 1:1 inclusion complex formed by the penetration of Cl-substituted aromatic ring into the β-CD cavity. The stoichiometry and binding constant of the complex were determined by Scott’s method.