Nancy L. Delgadillo-Armendariz, N. Rangel-Vázquez, Alejandra-Ibeth García-Castañón
Feb 24, 2014
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Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Abstract
The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both chitosan using theoretical calculations like Gibbs free energy, electrostatic potential, FTIR and NMR spectroscopy. Fourier transform infrared (FT-IR) spectroscopy reveals information about the molecular interactions of chemical components and is useful to characterization of hydrogel. Nucleophilic and electrophilic regions were calculated using the electrostatic potential.