A. Val'dman, M. Kozlovskaya, V. Klusha
Jun 1, 1980
Citations
0
Influential Citations
1
Citations
Journal
Bulletin of Experimental Biology and Medicine
Abstract
Melanostatin, a hypothalamic factor inhibiting the release of the melanocyte-stimulating hormone of the anter ior pituitary, has been isolated and identified as the tripeptide L-prolyl-L-leucylglycinamide. This same group is the C-terminal t r ipept ideof oxytocin, with the amino acid sequence 7-9 [11]. It potentiates the behavioral effects of L-dopa and 5-hydroxytryptophan and antagonizes oxotremorine t r emor in both intact and hypophysectomized animals, which indicates that melanostatin acts directly on the brain. On the basis of data indicating its dopamine-potentiating action, melanostatin has been used for the treai~nent of Parkinsonism in man [8, I0]. However, there is some evidence [51 that this effect of melanostatin differs from that of typical stimulators of dopamine receptors [7].