Lei Jin, Weiren Liu, Meng-Xin Tian
Apr 29, 2016
Citations
1
Influential Citations
23
Citations
Journal
World Journal of Surgical Oncology
Abstract
Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.