L. Rice, B. S. Sheth, J. Wheeler
Oct 1, 1973
Citations
0
Influential Citations
10
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
N-(2-Dimethylaminopropyl)-8,8-dimethyl-2-azaspiro[4.5]decane (1), N-(2-dimethylaminopropyl)-8,8-diethyl-2-azaspiro[4.5]decane (2), N-(3-dimethylaminopropyl)-9,9-dimethyl-3-azaspiro[5.5]undecane (3), and N-(3-dimethylaminopropyl)-9,9-diethyl-3-azaspiro[5.5]undecane (4) have been synthesized from 4,4-dimethylcyclohexanone (5) and 4,4-diethylcyclohexanone (6). Biological evaluation of these amines showed significant inhibition of cancer cell growth in human cancer cells grown in tissue culture.