Rena Nishizawa, Toshihiko Nishiyama, K. Hisaichi
Feb 1, 2007
Citations
1
Influential Citations
42
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Hydroxylated derivatives were designed and synthesized based on the information of oxidative metabolites. Compounds derived from beta-substituted (2R,3R)-2-amino-3-hydroxypropionic acid showed improved inhibitory activities against the binding of MIP-1alpha to human CCR5, compared with the non-hydroxylated derivatives and the other isomers.