Michael L. English, C. Stammer
Aug 29, 1978
Citations
1
Influential Citations
51
Citations
Journal
Biochemical and biophysical research communications
Abstract
Abstract A pentapeptide, Z-Gly-Gly-Phe-Phe-Ala · OH (1b) and the corresponding unsaturated pentapeptide, Z-Gly-Gly-Phe-Δ Z Phe-Ala · OH (1a) , have been synthesized. The saturated compound (1b) was rapidly hydrolyzed by both chymotrypsin and thermolysin to the expected products, but the dehydropeptide was completely unhydrolyzed by either enzyme even after thirty hours. A new method of peptide stabilization to enzymolysis is made available.