S. Tammilehto, K. Torniainen
Jun 1, 1989
Citations
0
Influential Citations
6
Citations
Journal
International Journal of Pharmaceutics
Abstract
Abstract Dothiepin, a tricyclic antidepressant, is slowly decomposed in aqueous solutions exposed to light. Artificial radiation from a high-pressure mercury lamp caused opening of the 7-ring and rearrangement of the molecule into a benzothiophene derivative. The main decomposition products in daylight were sulphoxides, with some other compounds formed in trace amounts. Glass capillary gas chromatography with non-polar OV-101 as liquid phase proved to be an accurate and reproducible procedure for monitoring of the isomerization and degradation of dothiepin.