M. Deshmukh, Sonali M. Salunkhe, D. R. Patil
Jun 1, 2009
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Influential Citations
187
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Quality indicators
Journal
European journal of medicinal chemistry
Abstract
The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against gram-positive and gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.