Tomoshige Hiratsuka, Hideaki Suzuki, A. Minami
Feb 1, 2017
Citations
1
Influential Citations
10
Citations
Journal
Organic & biomolecular chemistry
Abstract
Jawsamycin is a polyketide-nucleoside hybrid with a unique polycyclopropane moiety on a single polyketide chain. The unexpected isolation of cyclopropane deficient jawsamycin analogs allowed us to propose a stepwise cyclopropanation mechanism for the enzymatic synthesis of this polyketide. The concise timing of the cyclopropanation could be regulated by a delicate balance between reaction rates of the condensation and cyclopropanation reactions.