L. Angiolini, P. C. Bizzarri, M. Tramontini
1969
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
Abstract During the stereospecific synthesis of diastereoisomeric (+)-1-phenyl-1,2-dimethyl-3-dimethyl-amino-propan-1-ols (III and IV), obtained by reaction of suitable Grignard reagents on α-methyl-β-dimethylamino-propiophenone (I) or on 3-methyl-4-dimethylamino-butan-2-one (II) respectively, the absolute configuration of (−)-amino-alcohol (III) was shown to be 1 R , 2 S . It was also established that (−)-amino-alcohol (IV) has the 1 S , 2 S configuration.