M. LawrenceRonnie, PerlmutterPatrick
Feb 1, 1992
Citations
0
Influential Citations
11
Citations
Journal
Chemistry Letters
Abstract
In this paper we show that the stabilized carbanion dimethyl malonate adds to alkyl 2-(1-hydroxyalkyl)propenoates under basic conditions. Side reactions, such as lactonization or elimination, may be reduced and/or completely avoided by the use of phase transfer catalysis. The high stereoselectivity associated with the additions discussed here was found to be under thermodynamic control.