M. Midland, Young C. Kwon
1984
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
An efficient stereoselective synthesis of 22-R- and 22-S-hydroxy-23-acetylenic steroids has been developed using R-Alpine-Borane (125:1, R:S) and L-Selectride (1:11, R:S) to reduce the 22-keto steroid. S-Alpine-Borane provides an unexpectedly low 1:2.7, R:S ratio due to the influence of the α- chiral center at C-20 of the steroid.