J. Poisson, A. Orellana, A. Greene
Nov 18, 2005
Citations
0
Influential Citations
34
Citations
Journal
The Journal of organic chemistry
Abstract
[reaction: see text] A highly stereoselective synthesis of (-)-kainic acid has been achieved in 14 steps and >7% overall yield starting from inexpensive trans-4-hydroxy-L-proline. The key steps are diastereoselective enolate alkylation and cuprate substitution reactions.