James C. Anderson, Alice Flaherty
2001
Citations
0
Influential Citations
11
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
The first racemic synthesis of the non-proteinogenic amino acid (2S,3R,4R)-4-hydroxy-3-methylproline (1) has been achieved via iodolactonisation of an unnatural amino acid derivative 4. The relative stereochemistry was derived from an efficient silicon assisted aza-[2,3]-Wittig sigmatropic rearrangement of 2.