S. Djurić, M. Miyano, M. Clare
1987
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of a novel Prostacyclin/Carbacyclin analog 1a has been achieved in a stereocontrolled manner starting from the readily available bicyclic ketone 3 . A key strategic feature of the synthesis is a nucleophilic acetylide anion addition to 3 , the stereochemistry of which is predicted by MM2 calculations.