Takamitsu Utsukihara, O. Misumi, K. Nakajima
Mar 3, 2008
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0
Influential Citations
16
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Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
The stereoinversion of ortho-, meta- and para-substituted fluoro, chloro, bromo and methyl 1-phenylethanols using red alga (Cyanidioschyzon merolae) was investigated. It was found that 1-(4′-chlorophenyl)ethanol (1f) gave the corresponding (S)-alcohols in high ee and high yield (95%, 91% ee). On the other hand, stereoinversion of 1-(3′-chlorophenyl)ethanol (1e) indicated moderate ee (1e, 54% ee). In the case of 1-(2′-chlorophenyl)ethanol (1d), the biotransformation did not proceed. Moreover, we discuss about stereoinversion of alkyl group for secondary alcohols (3a–3d) and cis-2-methylcyclohexanol.