A. Volosov, B. Yagen, M. Bialer
Sep 1, 2000
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
Epilepsia
Abstract
Summary: Purpose: 10‐hydroxycarbazepine (MHD) is the active metabolite of the new antiepileptic drug oxcarbazepine. MHD is a chiral molecule with an asymmetric carbon at position 10. The purpose of this study was to evaluate the stereoselectivity in the pharmacokinetics of the enantiomers of MHD after oral administration of the individual MHD enantiomers and the racemic mixture to dogs.