R. Wykle, C. Miller, J. Lewis
Jun 30, 1981
Citations
0
Influential Citations
88
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract 1-O-Hexadecyl-2-O-acetyl- sn -glycero-3-phosphocholine (platelet activating factor) stimulated the degranulation of rabbit platelets and human neutrophils, whereas the enantiomer, 3-O-hexadecyl-2-O-acetyl- sn -glycero-1-phosphocholine, was inactive. The analogs compared had the following relative potencies in degranulating platelets and neutrophils: 1-O-hexadecyl-2-O-acetyl- sn -glycero-3-phosphocholine > 1-O-hexadecyl-2-O-ethyl- sn -glycero-3-phosphocholine > rac -1-O-octadecyl-2-O-ethylglycero-3-phosphocholine = 1-O-hexadecyl-2-O-methyl- sn -glycero-3-phosphocholine > rac -1-O-dodecyl-2-O-ethyl-glycero-3-phosphocholine. The deacetylated compound, 1-O-hexadecyl-2-lyso- sn -glycero-3-phosphocholine, and 1-O-hexadecyl-2,2-dimethylpropanediol-3-phosphocholine were inactive. The active analogs selectively desensitized the response to each other in the neutrophils. It is suggested that these compounds may activate cells through interaction with a stereospecific receptor.