M. Alauddin, P. Conti, T. Mathew
Oct 1, 2000
Citations
0
Influential Citations
22
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A detailed investigation on fluorination of 1,3,5-tri-O-benzoyl-α- d -ribofuranose-2-sulphonate esters is reported. Various combinations of sulfonate esters, fluorinating agents and solvents were evaluated in this study. Organic ammonium fluoride, in particular n-Bu4NF, was found to be better fluorinating agent than inorganic fluoride, and 1,3,5-tri-O-benzoyl-α- d -ribofuranose-2-trifluoromethylsulphonate ester appeared to be the best substrate. The developed method is suitable for stereospecific (arabino) incorporation of radiofluorine ( 18 F ) into the sugar moiety.