D. Ma, Jingyuan Ma, L. Dai
Mar 27, 1997
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract (1 S ,3 R )-Aminocyclopentane-1,3-dicarboxylic acid 1 , a widely used metabotropic glutamate receptor agonist has been synthesized. Hydrolysis followed by Curtius rearrangement of 5 derived from dimethyl ( S )-malate gave 6 with excellent diastereofacial selectivity (>97% de), which was converted into 1 through an S N 2 reaction of mesylate 7 with tetraethylammonium cyanide.