L. D. Smirnov, V. P. Lezina, V. Bystrov
Oct 1, 1965
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Journal
Russian Chemical Bulletin
Abstract
1. The course of aminomethylation and hydroxymethylation in the 2-alkyl-3-pyridinol series was studied with the aid of proton magnetic resonance and chemical methods. 2. Methods were developed for the synthesis of 6-(aminomethyl)-[6-(hydroxymethyl)-] and 4,6-bis(dialkylammo)-2-methyl-3-pyridinols. 3. The 6-mono(aminomethyl) derivative is formed at first, and this reacts further in the 4-position of the pyridine ring with formation of the 4,6-bis(dialkylaminomethyl) derivative. 4. 5-Hydroxy-6-methyl-2,4-pyridinedimethanol (isopyridoxine) was synthesized.