Jonathan Wolf Mueller, P. Foster
Aug 1, 2018
Citations
0
Influential Citations
2
Citations
Journal
Journal of molecular endocrinology
Abstract
Making and breaking conjugates of sulfate with highly biologically potent steroid hormones was discussed from various angles at SUPA2017, Targeting Steroid Sulfation Pathways. This Themed Scientific Meeting was held 23–25 April 2017, at the Medical School at the University of Birmingham, UK. This research field has come a long way since enzymatic sulfation of steroids was first described in 1955 (De Meio et al. 1955). Since then, scientific perspectives on why sulfated steroids exist have changed several times. Initially, sulfation was seen as a mere solubilization step readying these steroid forms for renal secretion. It took until the mid-2000s and the work by Michael Reed to suggest that sulfated steroids represent a circulating pool of steroid precursors that are bioavailable for cellular desulfation and thus fueling downstream steroid signaling (Reed et al. 2005). We have recently provided a comprehensive review on the dynamic interplay of steroid sulfation and desulfation and highlighted the impact of these pathways on normal physiology and on a multitude of disease states (Mueller et al. 2015). We also indicated where we lack knowledge on many aspects of steroid sulfation and desulfation. Thus, at SUPA2017, we welcomed about 50 participants with affiliations from 11 different nations to discuss these unknowns. The high intake of high-profile speakers from so many countries was only possible due to the generous support from the Society for Endocrinology (UK) via a Themed Scientific Meeting grant. Further, we were fortunate to be able to reach out to several pharmaceutical and scientific companies through support by a Medical Research Council (UK) Proximity-to-Discovery grant. This mixture provided unique opportunities for updates on the key advancements in this rapidly moving field, which we have tried to capture in this special issue. The steroid sulfation theme currently experiences growing research interest, which is adding novel insights about PAPS synthase and sulfotransferase function, novel analytics for steroid conjugate quantification and ripening drug development strategies (Foster & Mueller 2018). These strategies mainly target the steroid sulfatase enzyme with several compounds in development and in clinical trials (Potter 2018). Novel analytical approaches allow for detection and quantification of the previously neglected doubly sulfated steroid disulfates (Pozo et al. 2018), with the biological function of these disulfates to be better understood in the near future. The role of the steroid sulfatase pathway in the estrogen-dependent etiology and pathology of endometriosis is reviewed (Piccinato et al. 2018), highlighting targeting estrogen action as a potential therapy. Further, original research shows novel insights into the contribution of steroid sulfatase to the intracrine regulation of decidualization (Gibson et al. 2018). Sulfated steroids can also have roles within the central nervous system and the influence of steroid sulfatase on brain function, behavior and mental health during pregnancy is reviewed here (Davies 2018). High levels of circulating DHEA sulfate of adrenal origin may be unique to humans and great apes; however, porcine steroid metabolism is unique as Leydig cells can produce noticeable quantities of sulfated estrogens with high SULT1E1 expression detected in the epididymal head (Schuler et al. 2018). Interestingly, the expression of SULT2A1 and other steroidogenic enzymes was detected in porcine testis (Zimmer et al. 2018). A study about possible benefits of a sulfated resveratrol derivative may lead toward biotechnological applications of sulfation pathways (Correia-da-Silva et al. 2018). A scholarly review about the many and diverse marine sulfated steroids completes this special issue (Carvalhal et al. 2018); certainly, out there are many more sulfated compounds to discover and to make use in biotechnological applications. SUPA2017 was a high-profile and focused meeting of steroid sulfation researchers from around the globe and