Palwinder Singh, Arun Kumar, Sukhmeet Kaur
Apr 20, 2016
Citations
0
Influential Citations
5
Citations
Journal
MedChemComm
Abstract
We tailored 10H-acridin-9-one and (S)-tyrosine into 3-(4-hydroxyphenyl)-2-[(9-oxo-9,10-dihydroacridine-4-carbonyl) amino]propionic acid (2). 2 underwent pH dependent protonation/deprotonation and the effect was harnessed in terms of change in the fluorescence. The characteristic fluorescence change in the molecule in the pH 7.5 ± 1 range and its cell permeability allowed us to label cancer cells.