Necla Öztaşkın, S. Göksu, H. SeÇen
May 2, 2011
Citations
0
Influential Citations
19
Citations
Journal
Synthetic Communications
Abstract
Abstract 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine was synthesized from 2-naphthoic acid in six steps with an overall yield of 27%. Following the reaction sequence, bromination, esterification, substitution with NaOMe in the presence of CuI, the Birch reduction, Curtius rearrangement, and hydrogenolysis afforded biologically active title compound 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine as hydrogen chloride salt.